Polymeric Materials in the Physiological Environment
نویسنده
چکیده
The interactions between natural and synthetic materials and blood components are analyzed with emphasis on the interdependence between biomaterials research and development and ultimate applications. Two new synthetic polymers, perfluorobutyryl ethylcellulose and polyalkylsulfone, that combine desirable blood compatibility and gas-to-blood transfer rates are discussed in terms of their potential usefulness for membrane oxygenators. Among the several hydrogels, polyacrylamide covalently grafted onto segmented polyether-urethane substrates showed essentially no platelet adhesion and adsorbed the least plasma proteins in comparison to other systems. Polymeric composites having stiffness, anisotropies that approximate living tissues, and the ability to culture cells and hence to maintain a living cellular interface between flowing blood and microfiber substrates, are expected to expand the horizons for biomaterials in prosthetic applications.
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